VASCULAR BIOLOGY Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension
نویسندگان
چکیده
1Inserm U942, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Lariboisière, Service de Biochimie, Paris, France; 2Centre Chirurgical Marie Lannelongue, Le Plessis, Robinson, France; 3Inserm U970, Paris Centre de Recherche Cardiovasculaire, Hopital Européen Georges Pompidou, Paris, France; 4Inserm Unite Mixté de Recherche (UMR)–S 839, Université Pierre et Marie Curie and Institut du Fer à Moulin, Paris, France; 5Centre National de la Recherche Scientifique UMR 8147, Université Paris Descartes, Paris, France; and 6Université Paris-Sud 11, Inserm U999, Service de Pneumologie et Réanimation Respiratoire, Hôpital Antoine Béclère, AP-HP, Clamart, France
منابع مشابه
Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial dysfunction and vascular remodeling. Recently, bone marrow progenitor cells have been localized to PAH lungs, raising the question of their role in disease progression. Independently, serotonin (5-HT) and its receptors have been identified as contributors to the PAH pathogenesis. We hypothesized tha...
متن کاملOverexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation.
Overexpression of 5-Hydroxytryptamine 2B Receptor Gene in Pulmonary Hypertension: Still a Long Way to Understand its Transcriptional Regulation To the Editor: I have read with great interest the recent report by Liu1 concerning putative interactions between peroxisome proliferator-activated receptor (PPARγ) and 5-hydroxytryptamine 2B (5-HT2B) receptor in pulmonary arterial hypertension (PAH). P...
متن کاملResponse to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation.
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease, which involves pulmonary vasoconstriction and cardiovascular remodeling. Our present study shows that treatment with rosiglitazone, the peroxisome proliferator-activated receptor γ (PPARγ) agonist is able to attenuate 5-hydroxytryptamine (5-HT)-induced vasoconstriction of pulmonary arteries from monocrotalineor hypoxia-tr...
متن کاملJpet # 98269 1
A correlation between high plasma serotonin levels and total pulmonary resistance was reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic hypoxia (10% O2 for more than 3 weeks), wildtype mice develop lung vascular remodeling and pulmonary hypertension. We previously reported that, by contrast, the development of these hypoxiadependent alterations is totally a...
متن کاملPeroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.
An elevated plasma level of 5-hydroxytryptamine (5-HT) or upregulation of 5-HT receptor signaling or both is implicated in vascular contraction and remodeling in pulmonary arterial hypertension (PAH). Recently, peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to ameliorate PAH. However, their effects on the 5-HT-induced contraction of pulmonary arteries remain unkno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012